MMP3 Antibody 0 Publications

Mouse Monoclonal| Catalog number: 66338-1-Ig |CloneNo.: 1F5A9

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Freight/Packing

Con: 150 μg/150 μl

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Species specificity:
human, rat, mouse, pig

Positive WB detected in:
COLO 320 cells, Caco-2 cells, fetal human brain tissue, human heart tissue, pig heart tissue

Positive IHC detected in:
human breast cancer tissue, human breast cancer tissue, human stomach cancer tissue

Recommended dilution:
WB : 1:1000-1:4000
IHC : 1:50-1:500

Product Information


Source:
Mouse

Purification method:
Protein G purification

Isotype:
IgG1

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
matrix metallopeptidase 3 (stromelysin 1, progelatinase)

Calculated molecular weight:
477aa,54 kDa

Observed molecular weight:
45-60 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
MMP3

Synonyms
CHDS6, Matrix metalloproteinase 3, MMP 3, MMP3, SL 1, STMY, STMY1, STR1, Stromelysin 1, Transin 1
Background

Matrix metalloproteinases (MMPs) play a critically important role in extracellular matrix remodeling and have been implicated in a number of key normal and pathologic processes.These proteases have come to represent important therapeutic and diagnostic targets for the treatment and detection of human cancers. MMP-3 activate procollagenase via two pathways: slow direct activation and rapid activation in conjunction with tissue or plasma proteinases. The pro-MMP3 (60 kDa) and the active MMP3 (47 kDa) can be detected through western blot.


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