AEG-1/MTDH-Specific Antibody 26 Publications

Rabbit Polyclonal| Catalog number: 13860-1-AP

Featured Product KD/KO validated

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Freight/Packing

Con: 53 μg/150 μl

Choose size:

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Species specificity:
human, mouse, rat

Positive WB detected in:
MCF7 cells, A549 cells

Positive IP detected in:
MCF-7 cells

Positive IHC detected in:
human breast cancer tissue, human liver cancer tissue, human stomach cancer tissue, mouse brain tissue

Positive IF detected in:
MCF-7 cells

Recommended dilution:
WB : 1:500-1:2000
IP : 0.5-4.0 ug for IP and 1:500-1:2000 for WB
IHC : 1:50-1:500
IF : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
metadherin

Calculated molecular weight:
582aa,64 kDa

Observed molecular weight:
65-70 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
MTDH

Synonyms
3D3, 3D3/LYRIC, AEG 1, AEG1, LYRIC, LYRIC/3D3, metadherin, Metastasis adhesion protein, MTDH, Protein LYRIC
Background

MTDH, also known as AEG-1, is a single-pass transmembrane protein with its gene located at chromosome 8q22 , the abnormalities of which have been identified in several tumor types. MTDH is overexpressed in a number of malignancies, such as breast cancer, malignant glioma, and neuroblastoma , and its overexpression is associated with poor clinical outcome. MTDH plays an important role in the regulation of carcinogenesis and tumor progression. This antibody got two bands about 70 kDa and 80 kDa in western blotting, possibly due to posttranslational modification. This antibody is specific to AEG-1/MTDH.


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