Mcl-1 delta S/TM-specific Antibody 0 Publications

Rabbit Polyclonal| Catalog number: 15824-1-AP

  • Print page
  • Download PDF

-_-

Freight/Packing

Con: 20 μg/150 μl

Choose size:

Please visit your regions distributor:

Tested Applications

Applications:
ELISA
Application not tested? Please see our Guarantee




Species specificity:
human, mouse

Recommended dilution:

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Immunogen:
Peptide

Full name:
myeloid cell leukemia sequence 1 (BCL2-related)

Calculated molecular weight:
29 kDa

Observed molecular weight:

GenBank accession number:

Gene ID (NCBI):

Gene symbol
MCL1

Synonyms
EAT, Mcl 1, Mcl 1l, Mcl 1s Delta TM, MCL1, mcl1/EAT, MCL1L, MCL1S, TM
Background

MCL-1 is an anti-apoptotic member of the Bcl-2 family originally isolated from the ML-1 human myeloid leukemia cell line. Similar to BCL2 and BCL2L1, MCL1 can interact with BAX and/or BAK1 to inhibit mitochondria-mediated apoptosis. Mcl-1 is critical for the proliferation and survival of myeloma cells in vitro, and overexpression of Mcl-1 protein in myeloma cells is associated with relapse and short event-free survival in multiple myeloma patients. Recent studies show that MCL-1 is upregulated in numerous haematological and solid tumour malignancies. Therefore, MCL-1 has been suggested as a potential new therapeutic target. This antibody is specific to the short isoform Mcl-1 delta S/TM.


Back
to top