NCK1 Antibody 2 Publications

Rabbit Polyclonal| Catalog number: 15247-1-AP

Featured Product KD/KO validated

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Freight/Packing

Con: 32 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
mouse brain tissue, mouse liver tissue

Positive IP detected in:
mouse brain tissue

Positive IHC detected in:
human breast cancer tissue

Positive IF detected in:
Hela cells

Positive FC detected in:
HeLa cells

Recommended dilution:
WB : 1:500-1:2400
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB
IHC : 1:20-1:200
IF : 1:10-1:100

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
NCK adaptor protein 1

Calculated molecular weight:
43 kDa

Observed molecular weight:
43kd

GenBank accession number:

Gene ID (NCBI):

Gene symbol
NCK1

Synonyms
Cytoplasmic protein NCK1, NCK, Nck 1, NCK adaptor protein 1, NCK1, NCKalpha
Background

NCK family adaptor proteins function to couple tyrosine phosphorylation signals to regulate actin cytoskeletal reorganization that leads to cell motility. Cytoplasmic protein NCK1 (or NCK alpha) is an adapter protein which associates with tyrosine-phosphorylated growth factor receptors, such as KDR and PDGFRB, or their cellular substrates. NCK1 binds a number of intracellular proteins and influences various signaling pathways including GTPase-activating protein of Ras (RasGAP), which is responsible for the down-regulation of Ras. NCK1 is recently reported to regulate the UPR, which secondary to obesity impairs glucose homeostasis and insulin actions.


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