NXF1 Antibody 4 Publications

Rabbit Polyclonal| Catalog number: 10328-1-AP

Featured Product KD/KO validated

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Freight/Packing

Con: 31 μg/150 μl

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Species specificity:
human, mouse, rat, monkey

Positive WB detected in:
HeLa cells, HEK-293 cells

Positive IF detected in:
HepG2 cells

Recommended dilution:
WB : 1:500-1:1000
IF : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
nuclear RNA export factor 1

Calculated molecular weight:
70 kDa

Observed molecular weight:
66-70 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
NXF1

Synonyms
DKFZp667O0311, MEX67, mRNA export factor TAP, nuclear RNA export factor 1, NXF1, TAP, Tip associated protein, Tip associating protein
Background

Nuclear RNA export factor 1 (NXF1, synonyms: TAP, MEX67) is one member of a family of nuclear RNA export factors. Common domain features of this family are a noncanonical RNP-type RNA-binding domain (RBD), 4 leucine-rich repeats (LRRs), a nuclear transport factor 2 (NTF2)-like domain that allows heterodimerization with NTF2-related export protein-1(NXT1), and a ubiquitin-associated domain that mediates interactions with nucleoporins. The LRRs and NTF2-like domains are required for export activity. This protein shuttles between the nucleus and the cytoplasm and binds in vivo to poly(A)+ RNA. It is the vertebrate homologue of the yeast protein Mex67p. NXF1 overcomes the mRNA export block caused by the presence of saturating amounts of CTE (constitutive transport element) RNA of type D retroviruses.


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