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Teneurin 1 Polyclonal antibody

Teneurin 1 Polyclonal Antibody for IHC, WB, ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, IHC, ELISA

Conjugate

Unconjugated

Cat no : 21696-1-AP

Synonyms

ODZ1, ODZ3, Protein Odd Oz/ten m homolog 1, Ten 1, TEN M1, Tenascin M1, Teneurin 1, Teneurin-1, TNM, TNM1

Validation Data Gallery

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  • Western Blot (WB) analysis of H69/H146 cells using Teneurin 1 Polyclonal antibody (21696-1-AP)

    WB analysis of H69/H146 cells using 21696-1-AP

    WB result of anti-ODZ1 (21696-1-AP) with two cell lines by Dr. Petrini, Iacopo.

  • Western Blot (WB) analysis of various lysates using Teneurin 1 Polyclonal antibody (21696-1-AP)

    WB analysis using 21696-1-AP

    Various lysates were subjected to SDS PAGE followed by western blot with 21696-1-AP (ODZ1 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

  • Western Blot (WB) analysis of human brain tissue using Teneurin 1 Polyclonal antibody (21696-1-AP)

    WB analysis of human brain using 21696-1-AP

    human brain tissue were subjected to SDS PAGE followed by western blot with 21696-1-AP (ODZ1 antibody) at dilution of 1:1500 incubated at room temperature for 1.5 hours.

  • Western Blot (WB) analysis of mouse brain tissue using Teneurin 1 Polyclonal antibody (21696-1-AP)

    WB analysis of mouse brain using 21696-1-AP

    mouse brain tissue were subjected to SDS PAGE followed by western blot with 21696-1-AP (ODZ1 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

  • Immunohistochemistry (IHC) staining of human brain tissue using Teneurin 1 Polyclonal antibody (21696-1-AP)

    IHC staining of human brain using 21696-1-AP

    Immunohistochemical analysis of paraffin-embedded human brain tissue slide using 21696-1-AP (ODZ1 antibody) at dilution of 1:200 (under 10x lens. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

  • Immunohistochemistry (IHC) staining of human brain tissue using Teneurin 1 Polyclonal antibody (21696-1-AP)

    IHC staining of human brain using 21696-1-AP

    Immunohistochemical analysis of paraffin-embedded human brain tissue slide using 21696-1-AP (ODZ1 antibody) at dilution of 1:200 (under 40x lens. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

  • Immunohistochemistry (IHC) staining of mouse brain tissue using Teneurin 1 Polyclonal antibody (21696-1-AP)

    IHC staining of mouse brain using 21696-1-AP

    Immunohistochemical analysis of paraffin-embedded mouse brain tissue slide using 21696-1-AP (Teneurin 1 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

  • Immunohistochemistry (IHC) staining of mouse brain tissue using Teneurin 1 Polyclonal antibody (21696-1-AP)

    IHC staining of mouse brain using 21696-1-AP

    Immunohistochemical analysis of paraffin-embedded mouse brain tissue slide using 21696-1-AP (Teneurin 1 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

Tested Applications

Positive WB detected inmouse brain tissue, H69/H146 cells, human brain tissue, rat brain tissue
Positive IHC detected inhuman brain tissue, mouse brain tissue
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0

Recommended dilution

ApplicationDilution
Western Blot (WB)WB : 1:500-1:2000
Immunohistochemistry (IHC)IHC : 1:50-1:500
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Published Applications

WBSee 1 publications below

Product Information

21696-1-AP targets Teneurin 1 in WB, IHC, ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Reactivity human, mouse, rat
Cited Reactivityhuman
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen Teneurin 1 fusion protein Ag16289
Full Name odz, odd Oz/ten-m homolog 1(Drosophila)
Calculated Molecular Weight 2732 aa, 306 kDa
Observed Molecular Weight305 kDa
GenBank Accession NumberBC140783
Gene Symbol ODZ1
Gene ID (NCBI) 10178
RRIDAB_10858625
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.

Background Information

ODZ1 (also known as teneurin-1, TENM1), which plays a key role in central nervous system ontogenesis. ODZ1 is upregulated in Glioblastoma cells through a Stat3-mediated pathway activated by IL-6, which is released by tumor-associated monocytes. In addition, a hypoxic microenvironment regulates GBM tumor cell migration in part by inducing ODZ1 through hypomethylation of a CpG island in the ODZ1 promoter.

Protocols

Product Specific Protocols
WB protocol for Teneurin 1 antibody 21696-1-APDownload protocol
IHC protocol for Teneurin 1 antibody 21696-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols

Publications

SpeciesApplicationTitle
humanWB

Nature

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Authors - Barretina Jordi J
View Article