P2RX7 Antibody 5 Publications

Rabbit Polyclonal| Catalog number: 11144-1-AP

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Freight/Packing

Con: 22 μg/150 μl

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Species specificity:
human, mouse, rat

Positive IHC detected in:
human prostate cancer tissue, human tonsillitis tissue

Positive IF detected in:
HeLa cells

Positive FC detected in:
HeLa cells

Recommended dilution:
IHC : 1:20-1:200
IF : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
purinergic receptor P2X, ligand-gated ion channel, 7

Calculated molecular weight:
69 kDa

Observed molecular weight:

GenBank accession number:

Gene ID (NCBI):

Gene symbol
P2RX7

Synonyms
P2RX7, P2X7
Background

Nucleotides, the structural subunits of the nucleic acids, are also important extracellular signaling molecules. P2 receptors are a family of cell surface receptors that mediate a wide variety of physiologic effects in response to extracellular nucleotides. These receptors fall into two classes: P2X receptors, which are ligand-gated ion channels that mediate calcium and potassium fluxes in response to ATP, and P2Y receptors, which are G protein-coupled receptors (GPCRs) (PMID: 21724990). P2RX7 functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. P2RX7 is highly expressed by cells of the haemopoietic lineage and can mediate cell death, killing of infectious organisms, and regulation of the inflammatory response (PMID: 22102807).


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