Profilin 1 Antibody 3 Publications

Rabbit Polyclonal| Catalog number: 11680-1-AP

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Freight/Packing

Con: 56 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
human brain tissue, HeLa cells, Jurkat cells, NIH/3T3 cells

Positive IHC detected in:
human colon cancer tissue

Recommended dilution:
WB : 1:1000-1:6000
IHC : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
profilin 1

Calculated molecular weight:
140aa,15 kDa

Observed molecular weight:
15 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
PFN1

Synonyms
Epididymis tissue protein Li 184a, PFN1, Profilin 1, Profilin I
Background

Profilin-1 (PFN1) plays an important role in the control of actin dynamics, and could represent an important therapeutic target in several diseases. PFN1 is identified as a huntingtin aggregation inhibitor, and may serves as a tumor-suppressor. PFN1 is crucial for the conversion of monomeric (G)-actin to filamentous (F)-actin. Amyotrophic lateral sclerosis (ALS) is a late-onset neurodegenerative disorder resulting from motor neuron death. Cells expressing PFN1 mutants contain ubiquitinated, insoluble aggregates that in many cases contain the ALS-associated protein TDP-43. Recently, PFN1 is a potential biomarker for bladder cancer aggressiveness and may be of great clinical importance.


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