PIAS4 Antibody 0 Publications

Rabbit Polyclonal| Catalog number: 18469-1-AP

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Freight/Packing

Con: 78 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
HL-60 cells, Jurkat cells, K-562 cells

Positive IF detected in:
HeLa cells

Recommended dilution:
WB : 1:500-1:3000
IF : 1:50-1:500

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
protein inhibitor of activated STAT, 4

Calculated molecular weight:
57 kDa

Observed molecular weight:
57-70 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
PIAS4

Synonyms
E3 SUMO protein ligase PIAS4, FLJ12419, PIAS gamma, PIAS4, Piasg, PIASY, ZMIZ6
Background

PIAS4(protein inhibitor of activated STAT protein 4) is also named as PIASG, PIASy and belongs to the PIAS family. It enhanced the conjugation of SUMO2 to GATA2 through its E3 SUMO ligase activity. TGF-b can up-regulates PLAS4 expression in MCs to down-regulatea-SMA gene transcription by the interaction with E12 and PLAS4 predominantly acts as E3 ligases for E12 in MCs among PIAS family members(PMID:22829926). This protein can be sumoylated and Lys-35 is the main site of sumoylation(PMID:15831457).


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