PSEN1 Antibody 0 Publications

Rabbit Polyclonal| Catalog number: 20434-1-AP

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Freight/Packing

Con: 43 μg/150 μl

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Species specificity:
human

Positive IHC detected in:
human gliomas tissue

Positive IF detected in:
HEK-293 cells

Recommended dilution:
IHC : 1:50-1:200
IF : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
presenilin 1

Calculated molecular weight:
467aa,53 kDa

Observed molecular weight:

GenBank accession number:

Gene ID (NCBI):

Gene symbol
PSEN1

Synonyms
AD3, FAD, presenilin 1, Protein S182, PS 1, PS1, PS1 CTF12, PSEN1, PSNL1, S182
Background

PSEN1(presenilin-1) is also named as AD3, PS1, PSNL1 and belongs to the peptidase A22A family. It directly influences Netrin/DCC signaling with cell type precision and spatiotemporal specificity, and is a key neural circuit builder that gates the spatiotemporal pattern of guidance signaling, thereby ensuring neural projections occur with high fidelity(PMID:21215373). The 46-kDa PSEN1 holoprotein is cleaved into a D30-kDa N-terminal fragment (NTF) and a D20-kDa C-terminal fragment (CTF) by the 26S proteasome(PMID:10527805). It has 7 isoforms produced by alternative splicing. This antibody can recognize the isoform 4 (21 kDa) of this protein except the others.


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