PSEN2-Specific Antibody 0 Publications

Rabbit Polyclonal| Catalog number: 16168-1-AP

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Con: 20 μg/150 μl

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Species specificity:
human, mouse

Positive IHC detected in:
human kidney tissue, human breast cancer tissue, human colon tissue, human kidney tissue, human placenta tissue

Recommended dilution:
IHC : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Immunogen:
Peptide

Full name:
presenilin 2 (Alzheimer disease 4)

Calculated molecular weight:
50 kDa

Observed molecular weight:

GenBank accession number:

Gene ID (NCBI):

Gene symbol
PSEN2

Synonyms
AD3L, AD3LP, AD4, AD5, E5 1, Presenilin 2, PS 2, PS2, PSEN2, PSNL2, STM 2, STM2
Background

Presenilins can regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. These transmembrane proteins are considered to be involved in early onset of Alzheimer's disease. Presenilin 2 mainly localizes in large neurons. It exists in a heterodimeric complex formed from the endoproteolytically processed amino-terminal (34 kDa) and carboxy-terminal (about 23 kDa) fragments.This antibody is specific to presenilin 2. It will not bind presenilin 1.


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