Rab23 Antibody 2 Publications

Rabbit Polyclonal| Catalog number: 11101-1-AP

Featured Product KD/KO validated

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Freight/Packing

Con: 47 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
mouse brain tissue, rat brain tissue, HEK-293 cells, human brain tissue

Positive IP detected in:
mouse brain tissue

Positive IHC detected in:
human liver cancer tissue

Recommended dilution:
WB : 1:500-1:2000
IP : 0.5-4.0 ug for IP and 1:500-1:2000 for WB
IHC : 1:50-1:500

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
RAB23, member RAS oncogene family

Calculated molecular weight:
237aa,27 kDa

Observed molecular weight:
27 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
RAB23

Synonyms
DKFZp781H0695, HSPC137, RAB23, Ras related protein Rab 23
Background

Rab23 is a novel member of large Rab small GTPase family. It plays important roles during embryonic development. The brain-enriched Rab23 is the only Rab protein that is known to have a distinct function during central nervous system development, playing an essential role as a negative regulator of the Sonic Hedgehog (Shh) pathway. RAB23 has recently been identified in mesangial cells (MCs), and could serve as a biomarker that indicates the severity of FSGS ( focal segmental glomerulosclerosis). Mutations in RAB23 may result in ACPS2 ( acrocephalopolysyndactyly type 2).


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