Renin Antibody 2 Publications

Rabbit Polyclonal| Catalog number: 14291-1-AP

  • Print page
  • Download PDF

Be the first to review this product


-_-

Freight/Packing

Con: 25 μg/150 μl

Choose size:

Please visit your regions distributor:


Species specificity:
human, mouse, rat

Positive WB detected in:
rat kidney tissue, mouse heart tissue

Positive IHC detected in:
human kidney tissue, human gliomas tissue, human kidney tissue, mouse kidney tissue

Positive IF detected in:
HepG2 cells

Recommended dilution:
WB : 1:500-1:2000
IHC : 1:400-1:1600
IF : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
renin

Calculated molecular weight:
45 kDa

Observed molecular weight:
45-47 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
REN

Synonyms
Angiotensinogenase, FLJ10761, REN, Renin
Background

REN(Renin) is also named as angiotensinogenase and belongs to the peptidase A1 family. It is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney. Human prorenin and renin are synthesized in juxtaglomerular cells and it locates in the juxtaglomerular cells and afferent arteriole as cytoplasmic granules(PMID:19664745; PMID:9453303). This protein has a signal peptide of 23 amino acid and a propeptide of 43 amino acid. It has 2 isoforms produced by alternative splicing and two glycosylation sites. Defects in REN are a cause of renal tubular dysgenesis (RTD) and familial juvenile hyperuricemic nephropathy type 2 (HNFJ2).


Back
to top