Renin Antibody 4 Publications

Rabbit Polyclonal| Catalog number: 14291-1-AP

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Con: 25 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
rat kidney tissue, mouse heart tissue

Positive IHC detected in:
human kidney tissue, human gliomas tissue, mouse kidney tissue

Positive IF detected in:
HepG2 cells

Recommended dilution:
WB : 1:500-1:2000
IHC : 1:400-1:1600
IF : 1:20-1:200

Product Information


Purification method:
Antigen affinity purification


PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information

Full name:

Calculated molecular weight:
45 kDa

Observed molecular weight:
45-47 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol

Angiotensinogenase, REN, Renin

REN(Renin) is also named as angiotensinogenase and belongs to the peptidase A1 family. It is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney. Human prorenin and renin are synthesized in juxtaglomerular cells and it locates in the juxtaglomerular cells and afferent arteriole as cytoplasmic granules(PMID:19664745; PMID:9453303). This protein has a signal peptide of 23 amino acid and a propeptide of 43 amino acid. It has 2 isoforms produced by alternative splicing and two glycosylation sites. Defects in REN are a cause of renal tubular dysgenesis (RTD) and familial juvenile hyperuricemic nephropathy type 2 (HNFJ2).

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