RXRA Antibody 4 Publications

Rabbit Polyclonal| Catalog number: 21218-1-AP

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Freight/Packing

Con: 30 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
MCF7 cells, MCF-7 cells, rat liver tissue

Positive IP detected in:
MCF-7 cells

Positive IHC detected in:
human kidney tissue

Positive IF detected in:
Hela cells

Recommended dilution:
WB : 1:500-1:1000
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB
IHC : 1:20-1:200
IF : 1:10-1:100

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
retinoid X receptor, alpha

Calculated molecular weight:
462aa,51 kDa

Observed molecular weight:
50-54 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
RXRA

Synonyms
FLJ00280, FLJ00318, FLJ16020, FLJ16733, NR2B1, Retinoid X receptor alpha, retinoid X receptor, alpha, RXRA
Background

Retinoid X receptor alpha (RXRA). Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid. RXRA serves as a common heterodimeric partner for a number of nuclear receptors. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. The RXRA/PPARA heterodimer is required for PPARA transcriptional activity on fatty acid oxidation genes such as ACOX1 and the P450 system genes. This antibody is a rabbit polyclonal antibody raised against the 350 AA of human RXRA C-terminal. RXRA is highly expressed in liver, also expressed in lung, kidney and heart. It specifically recognizes the 51kd human RXRA protein.


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