SCNN1G Antibody 2 Publications

Rabbit Polyclonal| Catalog number: 13943-1-AP

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Con: 38 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
mouse lung tissue

Positive IHC detected in:
human colon cancer tissue

Recommended dilution:
WB : 1:500-1:2400
IHC : 1:50-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
sodium channel, nonvoltage-gated 1, gamma

Calculated molecular weight:
74 kDa

Observed molecular weight:
70-85 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
SCNN1G

Synonyms
ENaCg, ENaCgamma, Gamma ENaC, Gamma NaCH, PHA1, SCNEG, SCNN1G
Background

SCNN1G (sodium channel, nonvoltage-gated 1, gamma), also known as ENaC gamma (epithelial Na(+) channel subunit gamma) or amiloride-sensitive sodium channel subunit gamma, is the gamma subunit of the epithelial Na(+) channel (ENaC). ENaC is expressed in the apical membrane of salt-absorbing epithelia of kidney, distal colon, and lung. ENaC is a non-voltage gated, constitutively active channel highly selective for sodium. It has an essential role in salt and fluid homeostasis across epithelial tissues. Mutations in the gene of SCNN1G have been associated with Liddle syndrome. Native SCNN1G has a calculated molecular weight of 74 kDa and maybe undergo post-transcriptional modifications, including glycosylation and proteolytic cleavage (PMID: 12871941; 18086683).


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