SDHA Antibody 12 Publications

Rabbit Polyclonal| Catalog number: 14865-1-AP

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Freight/Packing

Con: 24 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
HEK-293 cells, HeLa cells, HepG2 cells, mouse brain tissue

Positive IP detected in:
mouse brain tissue

Positive IHC detected in:
human liver cancer tissue, human heart tissue, human kidney tissue, human liver cancer tissue

Positive IF detected in:
HepG2 cells, mouse brain tissue, mouse heart tissue, mouse liver tissue

Recommended dilution:
WB : 1:500-1:1000
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB
IHC : 1:100-1:400
IF : 1:10-1:100

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
succinate dehydrogenase complex, subunit A, flavoprotein (Fp)

Calculated molecular weight:
73 kDa

Observed molecular weight:
62-66 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
SDHA

Synonyms
FP, SDH2, SDHA, SDHF
Background

SDHA, also named as SDH2, SDHF and Fp, belongs to the FAD-dependent oxidoreductase 2 family and FRD/SDH subfamily. SDHA is the flavoprotein subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). SDHA has 3 isoforms with the molecular mass of 73, 67 and 57 kDa, and the N-terminal (~5 kDa) can be removed in mature form. It can be detected a band of 68 kDa in cutaneous melanoma(PMID:21698147). SDHA may act as a tumor suppressor.


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