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Neuroserpin Polyclonal antibody

Neuroserpin Polyclonal Antibody for WB,ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB,ELISA

Conjugate

Unconjugated

Cat no : 12558-1-AP

Synonyms

neuroserpin, Peptidase inhibitor 12, PI 12, PI12, Serpin I1, SERPINI1

Validation Data Gallery

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  • Western Blot (WB) analysis of mouse brain tissue using Neuroserpin Polyclonal antibody (12558-1-AP)

    WB analysis of mouse brain using 12558-1-AP

    mouse brain tissue were subjected to SDS PAGE followed by western blot with 12558-1-AP (Neuroserpin antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours.

Tested Applications

Positive WB detected inmouse brain tissue

Recommended dilution

ApplicationDilution
Western Blot (WB)WB : 1:500-1:1000
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

12558-1-AP targets Neuroserpin in WB,ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Reactivity human, mouse, rat
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen Neuroserpin fusion protein Ag3275
Full Name serpin peptidase inhibitor, clade I (neuroserpin), member 1
Calculated Molecular Weight 410 aa, 47 kDa
Observed Molecular Weight 46 kDa
GenBank Accession NumberBC018043
Gene Symbol SERPINI1
Gene ID (NCBI) 5274
RRIDAB_10642703
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.

Background Information

Neuroserpin is a member of the serpin family of serine protease inhibitors predominantly expressed in the nervous system, such as s the cerebral cortex, hippocampus and the spinal cord.Neuroserpin exerts protective effects in neurons against excitotoxicity both in vitro and in vivo. Its proteolytic inhibitory activity is shown to protect neurons against damage caused by plasmin activation. Mice overexpressing neuroserpin exhibited loss of tPA activity in the brain. Overexpression of neuroserpin in primary neurons leads to increased dendritic arborization and altered dendritic spine shape.

Protocols

Product Specific Protocols
WB protocol for Neuroserpin antibody 12558-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols