SHARPIN Antibody 33 Publications

Rabbit Polyclonal| Catalog number: 14626-1-AP

Featured Product KD/KO validated

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Freight/Packing

Con: 49 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
Raji cells, A549 cells, Jurkat cells

Positive IP detected in:
Raji cells

Positive IHC detected in:
human lymphoma tissue, human lymphoma tissue, human small intestine tissue

Recommended dilution:
WB : 1:500-1:3000
IP : 0.5-4.0 ug for IP and 1:500-1:3000 for WB
IHC : 1:100-1:400

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
SHANK-associated RH domain interactor

Calculated molecular weight:
40 kDa

Observed molecular weight:
40 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
SHARPIN

Synonyms
DKFZp434N1923, hSIPL1, SHARPIN, SIPL1
Background

SHARPIN is as a third component of the linear ubiquitin chain assembly complex (LUBAC), recruited to the CD40 and TNF receptor signaling complexes together with its other constituents, HOIL1 and HOIP(PMID:21455173).SHARPIN is enriched in the postsynaptic density and forms a complex with SHANK in heterologous cells and brain(PMID:11178875).It has 2 isoforms produced by alternative splicing.


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