STAT3 Antibody 2 Publications

Rabbit Polyclonal| Catalog number: 51076-2-AP

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Freight/Packing

Con: 51 μg/150 μl

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Species specificity:
human, mouse

Positive WB detected in:
K-562 cells, HeLa cells

Positive IP detected in:
HeLa cells

Positive IHC detected in:
human cervical cancer tissue,human lung cancer tissue, human breast cancer tissue

Recommended dilution:
WB : 1:500-1:1000
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB
IHC : 1:50-1:500

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Immunogen:
Peptide

Full name:
signal transducer and activator of transcription 3 (acute-phase response factor)

Calculated molecular weight:
770aa,88 kDa

Observed molecular weight:
88 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
STAT3

Synonyms
Acute phase response factor, APRF, FLJ20882, HIES, STAT3
Background

Signal transducer and activator of transcription 3 (acute-phase response factor) (STAT3, synonyms: APRF, FLJ20882, MGC16063) is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. STAT3 is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. STAT3 mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of STAT3. This antibody is a rabbit polyclonal antibody raised against a peptide mapping within human STAT3. STAT3 exists three isoforms and the molecular weight of each isoform respectively is 83 kDa, 87 kDa and 88 kDa.


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