STIM1 Antibody 0 Publications

Mouse Monoclonal| Catalog number: 66189-1-Ig |CloneNo.: 1D3A3

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Con: 150 μg/150 μl

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Species specificity:
rat, human, mouse

Positive WB detected in:
K-562 cells, Jurkat cells

Positive IHC detected in:
human lung cancer tissue, human lung cancer tissue, human ovary tumor tissue

Positive IF detected in:
HEK-293 cells

Recommended dilution:
WB : 1:500-1:1000
IHC : 1:50-1:500
IF : 1:50-1:500

Product Information


Source:
Mouse

Purification method:
Protein A purification

Isotype:
IgG2a

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
stromal interaction molecule 1

Calculated molecular weight:
685aa, 77 kDa

Observed molecular weight:
77 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
STIM1

Synonyms
Background

STIM1, also named as GOK, is an ER Ca2+ sensor. Upon Ca2+ store depletion, STIM1 clusters at ER–plasma membrane junctions where it interacts with and gates Ca2+-permeable Orai1 ion channels. STIM1 is implicated in tumor growth suppression and stromal-haematopoietic cell interactions. Defacts in STIM1 gene can cause immune dysfunction with impaired T-cell activation. STIM1 can inhibit L-type voltage-gated Ca(2+) channels in neurons. Temperature is an important regulator of STIM1 function.The MW of STIM1 is about 80-90 kDa which may be due to the phosphorylation or glycosylation forms.


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