Syntaxin 12 Antibody 1 Publications

Rabbit Polyclonal| Catalog number: 14259-1-AP

Featured Product KD/KO validated

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Freight/Packing

Con: 25 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
mouse brain tissue, BxPC-3 cells, human brain tissue, human heart tissue, mouse heart tissue

Positive IHC detected in:
human lung cancer tissue, human brain tissue, human kidney tissue, human lung cancer tissue, human pancreas tissue

Positive IF detected in:
HepG2 cells

Positive FC detected in:
HepG2 cells

Recommended dilution:
WB : 1:500-1:2000
IHC : 1:20-1:200
IF : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
syntaxin 12

Calculated molecular weight:
32 kDa

Observed molecular weight:
33kd,39kd,66kd

GenBank accession number:

Gene ID (NCBI):

Gene symbol
STX12

Synonyms
STX12, STX13, STX14, syntaxin 12
Background

Syntaxin 12 (STX12), also known as STX13 or STX14, is a 276 amino acid single-pass type IV membrane protein that belongs to the syntaxin family. It is a broadly and differentially expressed SNARE protein, highly enriched in brain tissue. STX12 is localized to early and recycling endosomes and is involved in the recycling of plasma membrane proteins. It also has a role in the trafficking of MMP during degradation of ECM substrates and subsequent cellular invasion. (PMID: 9507000; 9553086; 19910495) This antibody recognizes a major 39 kDa band of endogenous STX12. In some cases, two additional bands of 33 kDa and 66 kDa could also be detected, which most likely represent a degradation product and a SNARE complex respectively (PMID: 9817754).


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