Sestrin 2 Antibody 73 Publications

Rabbit Polyclonal| Catalog number: 10795-1-AP

Featured Product KD/KO validated

  • Print page
  • Download PDF

-_-

Freight/Packing

Con: 72 μg/150 μl

Choose size:

Please visit your regions distributor:


Species specificity:
human, mouse, rat

Positive WB detected in:
HEK-293 cells, HEK-293

Positive IP detected in:
K-562 cells

Positive IHC detected in:
human colon cancer tissue, human breast cancer tissue, human colon cancer tissue, human ovary tumor tissue

Positive IF detected in:
Hela cells

Recommended dilution:
WB : 1:500-1:2000
IP : 0.5-4.0 ug for IP and 1:500-1:2000 for WB
IHC : 1:100-1:400
IF : 1:10-1:100

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
sestrin 2

Calculated molecular weight:
54 kDa

Observed molecular weight:
54-60 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
SESN2

Synonyms
DKFZp761M0212, DKFZp761M02121, HI95, SES2, SESN2, SEST2, Sestrin 2, Sestrin-2
Background

SESN is a family of highly conserved, stress-inducible genes that can defend the cell against oxidative damage and oncogenic signaling. SESN2 ,which belongs to the SESN family, has been implicated as a tumor suppressor that can inhibit angiogenesis and promote autophagy, underscoring the importance of elucidating the molecular mechanism by which SESN2 regulates pathways of metabolism and survival.(PMID:22363791). Sesn2 encodes a 480 amino acid protein which can run as a 60 kDa band on SDS-polyacrylamide gel electrophoresis(PMID:20878915).


Back
to top