TLE3 Antibody 0 Publications

Mouse Monoclonal| Catalog number: 66083-1-Ig |CloneNo.: 1D11A8

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Freight/Packing

Con: 92 μg/150 μl

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Species specificity:
human

Positive WB detected in:
293 cells, HEK-293 cells

Positive IP detected in:
HEK-293 cells

Positive IHC detected in:
human breast cancer tissue

Recommended dilution:
WB : 1:500-1:2000
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB
IHC : 1:20-1:200

Product Information


Source:
Mouse

Purification method:
Protein G purification

Isotype:
IgG1

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)

Calculated molecular weight:
772aa,83 kDa

Observed molecular weight:
90 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
TLE3

Synonyms
ESG, ESG3, FLJ39460, GRG3, HsT18976, KIAA1547, TLE3
Background

TLE3, also named as KIAA1547 and ESG3, belongs to the WD repeat Groucho/TLE family. It is a transcriptional corepressor that binds to a number of transcription factors. It inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. TLE3 is a member of the transducin-like enhancer of split (TLE) family of proteins that have been implicated in the tumorgenesis and classification of sarcomas. It is a candidate biomarker of response to taxane therapy.(PMID:19309506 )


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