TMEM106B Antibody 0 Publications

Mouse Monoclonal| Catalog number: 60333-1-Ig |CloneNo.: 5D1F8

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Con: 222 μg/150 μl

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Species specificity:
human

Positive WB detected in:
U-251 cells,HeLa cells

Positive IHC detected in:
human cerebellum tissue

Recommended dilution:
WB : 1:500-1:2000
IHC : 1:50-1:500

Product Information


Source:
Mouse

Purification method:
Protein G purification

Isotype:
IgG1

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
transmembrane protein 106B

Calculated molecular weight:
31 kDa

Observed molecular weight:
~40 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
TMEM106B

Synonyms
FLJ11273, TMEM106B, transmembrane protein 106B
Background

TMEM106B is a genetic risk factor for frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP). Amyotrophic lateral sclerosis (ALS), like FTLD-TDP, is characterized by pathological TDP-43 inclusions. TMEM106B expression in the brain may be linked to mechanisms of disease in FTLD-TDP and risk alleles confer genetic susceptibility by increasing gene expression.


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