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Tetraspanin-3 (TSPAN3, also known as TM4SF8) is a member of the tetraspanin (TM4SF) family. Tetraspanins, so named because they contain four transmembrane domains, are frequently expressed at the cell surface in association with each other and with other molecules, and they function to regulate cell adhesion, migration, proliferation, and differentiation. TSPAN3 regulates the proliferation and migration of oligodendrocytes, a process essential for normal myelination and repair.