Thioredoxin Antibody 10 Publications

Rabbit Polyclonal| Catalog number: 14999-1-AP

Featured Product KD/KO validated

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Freight/Packing

Con: 63 μg/150 μl

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Species specificity:
human, mouse, rat, chicken

Positive WB detected in:
Jurkat cells, A2780 cells, HeLa cells, human brain tissue, human liver tissue, Jurkat cells, mouse liver tissue, rat brain tissue

Positive IP detected in:
Jurkat cells

Positive IHC detected in:
human liver tissue, human cervical cancer tissue, human liver tissue, human skeletal muscle tissue

Positive IF detected in:
Hela cells

Positive FC detected in:
HeLa cells

Recommended dilution:
WB : 1:1000-1:4000
IP : 0.5-4.0 ug for IP and 1:200-1:1000 for WB
IHC : 1:100-1:400
IF : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
thioredoxin

Calculated molecular weight:
12 kDa

Observed molecular weight:
12 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
TXN

Synonyms
ADF, ATL derived factor, DKFZp686B1993, SASP, Thioredoxin, TRDX, TRX, TRX1, TXN
Background

TXN, TRDX, TRX, TRX1, ADF and SASP, belongs to the thioredoxin family. It participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. TXN plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. TXN induces the FOS/JUN AP-1 DNA-binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity.


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