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VAMP2 Antibody 3 Publications

Goat Polyclonal| Catalog number: 30001-0-AP

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Con: 60 μg/150 μl

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Tested Applications

Applications:
WB, ELISA
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Species specificity:
human
Positive WB detected in:
Mouse brain tissue
Recommended dilution:
WB : 1:1000-1:4000

Protocols

Product-specific protocols

Standard Protocols

Product Information

Source:
Goat
Purification method:
Antigen affinity purification
Isotype:
IgG
Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information

Immunogen:
Recombinant Protein
Full name:
vesicle-associated membrane protein 2 (synaptobrevin 2)
Calculated molecular weight:
13 kDa
Observed molecular weight:
GenBank accession number:
NM_014232
Gene ID (NCBI):
6844
Gene symbol
VAMP2
Synonyms
SYB2, Synaptobrevin 2, VAMP 2, VAMP2

Background

VAMP2 (vesicle-associated membrane protein 2), also named as synaptobrevin 2, is a member of the SNARE (soluble NSF-attachment protein receptor) family of proteins. Characterized by a common sequence called the SNARE motif, SNARE proteins are involved in membrane fusion and vesicular transport (PMID: 11252968). VAMP2 consists of a short N-terminal sequence, a SNARE motif, and a C-terminal transmembrane region. It is required for fast calcium-triggered synaptic vesicle fusion. VAMP2 forms a stable complex with STX1 (syntaxin 1) and SNAP25 (synaptosomal-associated protein 25) during synaptic vesicle fusion (PMID: 16793874). It also forms a distinct complex with synaptophysin. VAMP2 is expressed in nervous system and some non-neuronal tissues, such as skeletal muscle (PMID: 18570252).


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