p504S,AMACR Antibody 0 Publications

Mouse Monoclonal| Catalog number: 60240-1-Ig |CloneNo.: 2H9B5

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Freight/Packing

Con: 75 μg/150 μl

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Species specificity:
human, mouse

Positive WB detected in:
HEK-293 cells

Recommended dilution:
WB : 1:500-1:2000

Product Information


Source:
Mouse

Purification method:
Protein G purification

Isotype:
IgG1

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
alpha-methylacyl-CoA racemase

Calculated molecular weight:
382aa,42 kDa

Observed molecular weight:
42kd

GenBank accession number:

Gene ID (NCBI):

Gene symbol
AMACR

Synonyms
AMACR, RACE, p504S, CBAS4, alpha methylacyl CoA racemase
Background

AMACR(Alpha-methylacyl-CoA racemase) belongs to the CaiB/BaiF CoA-transferase family. It is a mitochondrial and peroxisomal enzyme that catalyzes the conversion of 2R stereoisomers of phytanic and pristanic acid to their S counterparts. AMACR has previously been shown to be a highly sensitive marker for colorectal and clinically localized prostate cancer (PCa). However, AMACR expression is down-regulated at the transcript and protein level in hormone-refractory metastatic PCa, suggesting a hormone-dependent expression of AMACR(PMID:12213712). It has 3 isoforms produced by alternative splicing. Defects in AMACR are the cause of alpha-methylacyl-CoA racemase deficiency (AMACRD) and congenital bile acid synthesis defect type 4 (CBAS4).


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