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AKT Signaling: New Pathway Poster

Download a pathway poster for your lab.

All the posters in the Proteintech library are available in PDF format or can be requested as a hard copy.

Overview: AKT Signaling and Cancer

The serine/threonine kinase B AKT pathway (also known as the PI3K-Akt pathway) plays a vital role in the regulation of cellular processes, including cell proliferation, survival, and growth – processes that are essential for oncogenesis (D Altomare and J Testa, 2005) (Ji Luo et al., 2003).

Mutation of the regulator proteins PI3K and PTEN causes uncontrolled disruption within the PI3-kinase pathway, leading to the development of human cancers. Targeting the deregulation of PI3K/PTEN-Akt signaling has recently emerged as a potential therapy in anticancer drug development (Zhang S and Yu D, 2010).

Download the AKT signaling pathway poster here

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D Altomare and J Testa. (2005). Perturbations of the AKT signaling pathway in human cancer. Oncogene. 24, p7455–7464.

Ji Luo, Brendan D Manning et al. (2003). Targeting the PI3K-Akt pathway in human cancer. Cancer Cell. 4 (4), p257–262.

Zhang S and Yu D. (2010). PI(3)king apart PTEN’s role in cancer. Clinical Cancer Research. 16 (17), p4325–30.


26 April, 2017


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