All the posters in the Proteintech library are available in PDF format or can be requested as a hard copy.
The serine/threonine kinase B AKT pathway (also known as the PI3K-Akt pathway) plays a vital role in the regulation of cellular processes, including cell proliferation, survival, and growth – processes that are essential for oncogenesis (D Altomare and J Testa, 2005) (Ji Luo et al., 2003).
Mutation of the regulator proteins PI3K and PTEN causes uncontrolled disruption within the PI3-kinase pathway, leading to the development of human cancers. Targeting the deregulation of PI3K/PTEN-Akt signaling has recently emerged as a potential therapy in anticancer drug development (Zhang S and Yu D, 2010).
|AKT (KD/KO validated)||p53 (KD/KO validated)||GSK3A|
|AKT1 (KD/KO validated)||MTOR||GSK3B (KD/KO validated)|
|AKT2||PI3K p110 (alpha)||Raptor (KD/KO validated)|
|AKT3||PI3K p110 (beta)||CREB1|