Alzheimer's Disease Signaling Pathway
Download or request a pathway poster for your lab
All the posters in the Proteintech library are available in PDF format or can be requested as a hard copy.
Nowadays Alzheimer's disease (AD) alone accounts for between and 60 and 70% of all dementia cases. AD is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs), where amyloid beta is a major component of these plaques. From a genetic perspective, four genes are deeply involved in AD: amyloid precursor protein (APP), presenilin 1 (PS1), presenilin2 (PS2), and apolipoprotein E (ApoE). Mutations in APP and PS proteins provoke an increase of amyloid-beta peptides, mostly the amyloidogenic form – amyloid-beta 42. The correlation between APOE and AD is significant; however, APOE genotyping is neither fully specific nor sensitive.
Popular Alzheimer's Disease Antibodies
|AP repeat||Cytochrome C||MME,CD10|
|Ihc of paraffin-embedded human brain tissue slide using 10274-1-AP( TAU Antibody) at dilution of 1:200 (under 40x lens)||IHC of paraffin-embedded human brain using 10782-2-AP(TARDBP antibody) at dilution of 1:50 (under 40x lens)|