AMPK Signaling: New Pathway Poster

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AMPK Pathway Overview

One of the central regulators of cellular and organismal metabolism in eukaryotes is AMP-activated protein kinase (AMPK). AMPK is a master regulator of cellular energy homeostasis and has recently been connected to cellular processes such as autophagy and cell polarity (1). AMPK has also been implicated in several species as a critical modulator of aging through its interactions with mTOR or sirtuins. The kinase is activated in response to stresses that deplete cellular ATP supplies such as low glucose, hypoxia, ischemia, and heat shock. In mammals, there are two genes encoding the AMPK α catalytic subunit (α1 and α2), two β genes (β1 and β2), and three γ subunit genes (γ1, γ2, and γ3) (2).

Due to its role as a central regulator of both lipid and glucose metabolism, AMPK is considered to be a potential therapeutic target for the treatment of type II diabetes mellitus, obesity, and cancer (3 and 4).

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Related Antibodies

References

1. The AMPK signalling pathway coordinates cell growth, autophagy and metabolism

2.. AMPK activators: mechanisms of action and physiological activities

3. AMPK: an emerging drug target for diabetes and the metabolic syndrome.

4. Targeting AMPK for cancer prevention and treatment