IL-6 Signaling : New Pathway poster

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IL-6 Signaling Overview

Interleukin-6 (IL-6) is an endogenous chemical with multiple forms and functions. It acts as both a pro and an anti-inflammatory cytokine (1). In the early phase of infectious inflammation, IL-6 is produced by monocytes and macrophages immediately after the stimulation of Toll-like receptors (TLRs) with distinct pathogen-associated molecular patterns (PAMPs). In non-infectious inflammation, such as a burn or traumatic injury, damage-associated molecular patterns (DAMPs) from damaged or dying cells stimulate TLRs to produce IL-6 (2).

IL-6 helps T-cells to differentiate in their development. It is required for progenitor cell development or helps B-cells differentiate and proliferate, and promotes the formation of plasma cells from B-cells. IL-6 also plays a vital role in the development of blood cells, whether white cells, red cells or platelets. Besides, IL-6 leads to the activation of osteoclasts and osteoporosis. It also induces the secretion of vascular endothelium growth factor (VEGF), which leads to the increased growth of blood vessels and vascular permeability in inflammation (3).

Genetic variations of IL6 are associated with rheumatoid arthritis systemic juvenile (RASJ), and its promoter polymorphism can be an indicator for Kaposi sarcoma development in HIV-infected men (4-5).

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Related Antibodies

Antibody Type Catalog Number Publications
IL-6 Antibody KD/KO Validated Rabbit polyclonal 21865-1-AP 32
IL-6 Antibody Mouse monoclonal 66146-1-Ig 2
AKT1 Antibody  KD/KO Validated Rabbit Polyclonal 10176-2-AP 77
ERK1/2 Antibody Mouse Monoclonal 66192-1-Ig   4
GRB2 Antibody KD/KO Validated Rabbit Polyclonal 10254-2-AP  3
IKBKG Antibody KD/KO Validated Rabbit Polyclonal 18474-1-AP 7
MTOR Antibody Rabbit Polyclonal  20657-1-AP 20
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References

  1. The pro- and anti-inflammatory properties of the cytokine interleukin-6.
  2. IL-6 as a keystone cytokine in health and disease.
  3. The many faces of interleukin-6: the role of IL-6 in inflammation, vasculopathy, and fibrosis in systemic sclerosis.
  4. New insights in systemic juvenile idiopathic arthritis--from pathophysiology to treatment.
  5. An IL6 promoter polymorphism is associated with a lifetime risk of development of Kaposi sarcoma in men infected with human immunodeficiency virus.
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Posted:
14 June, 2017

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