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Dr. Allison Porman of the Aaron M. Johnson lab in the University of Colorado discusses the molecular mechanisms of the lncRNA HOTAIR and other epigenetic factors in this installment of Webinar Wednesdays.
In 1958, Francis Crick proposed the central dogma of molecular biology: DNA is transcribed to RNA and translated to Proteins. As our understanding of biology has advanced, the model has become more complicated, especially with the discovery of epigenetic mechanisms. A major player in these new mechanisms is long non-coding RNA (lncRNA), which can influence gene expression through epigenetic writer protein recruitment. An example of this is XIST, which recruits the PRC2 complex to silence X chromosomes in females. Another lncRNA, HOTAIR, is recruits the PRC2 complex to silence metastatic restricting genes and promote cancer development. Watch Dr. Porman's webinar to learn more!
HOTAIR is implicated in breast cancer metastasis.
hnRNP B1 helps HOTAIR target genes for H3K27 methylation.
N6-methyladenosine (m6a) RNA modification is needed for silencing by other lncRNA. Could it play a role in HOTAIR's silencing of tumor suppressor genes?
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