KCTD7 Polyclonal antibody

• 

  WB analysis using 32488-1-AP

  Various lysates were subjected to SDS PAGE followed by western blot with 32488-1-AP (KCTD7 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

KCTD7 Polyclonal Antibody for WB, ELISA

Cat No. 32488-1-AP

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, ELISA

Synonyms

BTB/POZ domain-containing protein KCTD7

---

Tested Applications

• Positive WB detected in: human placenta tissue, human testis tissue

Recommended dilution

• Western Blot (WB): WB : 1:500-1:2000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, Check data in validation data gallery.

Product Information

32488-1-AP targets KCTD7 in WB, ELISA applications and shows reactivity with human samples.

• Tested Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen: KCTD7 fusion protein Ag35756
• Full Name: potassium channel tetramerisation domain containing 7
• Calculated Molecular Weight: 33 kDa，289 aa
• Observed Molecular Weight: 62 kDa
• GenBank Accession Number: NM_153033.4
• Gene Symbol: KCTD7
• Gene ID (NCBI): 154881
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity Purification
• UNIPROT ID: Q96MP8
• Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.
• Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20^oC storage. 20ul sizes contain 0.1% BSA.

Background Information

KCTD7, or Potassium Channel Tetramerization Domain Containing 7, is a member of the KCTD family of proteins. The role of KCTD7 in regulating autophagy-lysosome pathways, which are essential for cellular homeostasis and response to nutrient stress (PMID: 36964131). It has been implicated in several neurodegenerative disorders, particularly progressive myoclonic epilepsy (PME) and neuronal ceroid lipofuscinosis (NCL). The deficiency of KCTD7 results in the accumulation of lipofuscin and lipid droplets, which are hallmarks of NCL (PMID: 33970744). The 62 kDa form most likely corresponds to an SDS-stable dimer (PMID: 22748208).