THAP1 Antibody 7 Publications

Rabbit Polyclonal| Catalog number: 12584-1-AP

Featured Product KD/KO validated

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Con: 75 μg/150μl

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Species specificity:
human, mouse, rat, mouse; human

Positive WB detected in:
HEK-293 cells, A375 cells, HEK-293 cells, HeLa cells, HepG2 cells, human brain tissue, human heart tissue, mouse brain tissue, mouse heart tissue, SGC-7901 cells

Positive IHC detected in:
human colon cancer tissue

Recommended dilution:
WB : 1:500-1:5000
IHC : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
THAP domain containing, apoptosis associated protein 1

Calculated molecular weight:
213aa,25 kDa

Observed molecular weight:
30kd

GenBank accession number:

Gene ID (NCBI):

Gene symbol
THAP1

Synonyms
FLJ10477, THAP1
Background

THAP1 belongs to the THAP1 family. It is a DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. THAP1 may also have pro-apoptopic activity by potentiating both serum-withdrawal and TNF-induced apoptosis. Mutations in THAP1 have been associated with dystonia 6. THAP1 encodes a transcription factor with mostly unknown targets. It regulates the expression of DYT1 (TOR1A), another dystonia-causing gene. After characterization of the TOR1A promoter, THAP1 binds to the core promoter of TOR1A. Wild type THAP1 represses the expression of TOR1A, whereas dystonia 6-associated mutant THAP1 results in decreased repression of TOR1A. Catalog#12584-1-AP is a rabbit polyclonal antibody raised against full-length of huamn THAP1.


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