Anti-Mouse TIGIT (1G9)

TIGIT Monoclonal Antibody for FC

Host / Isotype

Mouse / IgG1

Reactivity

Mouse

Applications

FC

Conjugate

Unconjugated

CloneNo.

1G9

Cat no : 65079-1-Ig

Synonyms

ENSMUSG00000071552, Tigit, Vstm3



Recommended dilution

ApplicationDilution
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

65079-1-Ig targets TIGIT in FC applications and shows reactivity with Mouse samples.

Tested Reactivity Mouse
Host / Isotype Mouse / IgG1
Class Monoclonal
Type Antibody
Immunogen Cells
Full Name T cell immunoreceptor with Ig and ITIM domains
GenBank Accession NumberNM_001146325
Gene Symbol Tigit
Gene ID (NCBI) 100043314
Conjugate Unconjugated
Form Liquid
Purification MethodAffinity purification
Storage Buffer 10 mM NaH2PO4, 150 mM NaCl, 0.09% NaN3, 0.1% gelatin, pH7.2.
Storage ConditionsStore at 2-8°C.

Background Information

TIGIT (T-cell immunoreceptor with Ig and ITIM domains), also known as VSIG9 or VSTM3, is an immune receptor expressed on T cells, including Treg and memory subsets, as well as on NK cells (PMID: 19011627). It contains an immunoglobulin variable domain, a transmembrane domain and an immunoreceptor tyrosine-based inhibitory motif (ITIM). TIGIT binds to poliovirus receptor (PVR, also called CD155) with high affinity, and also to PVRL2 (CD112) with lower affinity. The interaction of TIGIT with PVR on dendritic cells increases the secretion of IL-10 and decreases the secretion of proinflammatory cytokine and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells. TIGIT can inhibit NK cytotoxicity directly through its ITIM (PMID: 19815499).