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NF-κB Antibody

Overview, pathway and related antibodies

Overview, pathway and related antibodies


Nuclear factor kappa B (NF-κB) is a protein complex that controls transcription of DNA, cytokine production and cell survival. NF-κB is composed of multiple subunits: RelA (p65), RelB, c-Rel, NF-κB1 (p50) and NF-κB2 (p52) (1).

These proteins function as dimeric transcription factors that regulate the expression of genes influencing a broad range of biological processes including innate and adaptive immunity, inflammation, stress responses, B-cell development, and lymphoid organogenesis (2). NF-κB exists freely in the cytoplasm, where it is inhibited by IκB proteins. In the classical (canonical) pathway, NF-κB activation occurs through the phosphorylation, ubiquitination and subsequent proteosomal degradation of IκB. An alternative (non-cononical) activation involves phosphorylation and processing of the p52 precursor, p100 into the mature protein and subsequent nuclear translocation of the RelB/p52, heterodimer that translocate to the nucleus and induce target gene expression (3).

Abnormalities in NF-κB pathway has been linked to cancer, inflammatory and autoimmune diseases, septic shock, viral infection, and improper immune development. NF-κB has also been implicated in processes of synaptic plasticity and memory (4,5).

Download the NF-KB Pathway as a PDF here
Antibody Catalog number Type Applications  
NF-ΚB 14220-1-AP Rabbit Poly ELISA, IF, IHC, IP, WB 24 Publications
P65; RELA - KD/KO Validated 10745-1-AP Rabbit Poly ELISA, FC, IF, IHC, IP, WB 128 Publications
NFKB2 10409-2-AP Rabbit Poly ELISA, IF, IHC, IP, WB 3 Publications
NFKB1 23576-1-AP Rabbit Poly ELISA, WB, IHC, IF  
NF-κB antibody validated in IF Immunofluorescent analysis of ( -20°C Ethanol) fixed HepG2 cells using 14220-1-AP (NF-κB antibody) at dilution of 1:50 and Alexa Fluor 488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L)

References:

  1. The NF-kappaB pathway.
  2. Shared principles in NF-kappaB signaling.
  3. Introduction to NF-kappaB: players, pathways, perspectives.
  4. The NF-κB activation pathways, emerging molecular targets for cancer prevention and therapy.
  5. NF-κB in the Nervous System

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Posted:
28 April, 2020

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