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PGP9.5 Antibody

Proteintech's UCHL1/PGP9.5 antibody

Proteintech's UCHL1/PGP9.5 antibody

UCHL1/PGP9.5 Antibody

The pan neuronal-marker UCHL1/PGP9.5

UCHL1/PGP9.5 as a tumor marker

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"Robust and bright in fluorescent IHC...simply put, it just works."

- Brian Lin, Tufts University

UCHL1/PGP9.5 Antibody

UCHL1 (Ubiquitin carboxyl-terminal hydrolase isozyme L1) is known under several names, such as neuron cytoplasmic protein 9.5, PGP9.5, or PARK5. 

It is a member of a gene family whose products hydrolyze small C-terminal adducts of ubiquitin to generate the ubiquitin monomer. This function is also important to remove ubiquitin from partially degraded proteins. Several different diseases are associated with the dysfunction of the ubiquitin pathway.

IF result of UCHL1 (14730-1-AP, 1:300) with 1% PLP fixed adult mouse olfactory epithelium. (Red: CK14; Green: UCHL1; Blue: DAPI). By Brian Lin, Tufts University

IF result of UCHL1 (14730-1-AP, 1:300) with 1% PLP fixed adult mouse olfactory epithelium. (Red: CK14; Green: UCHL1; Blue: DAPI). By Brian Lin, Tufts University.

Antibody Name Cat no.  Type Applications Citations
PGP9.5/UCHL1 14730-1-AP Rabbit Poly WB, IP, IHC, IF, CoIP, ELISA 25

The pan neuronal-marker UCHL1/PGP9.5

The expression of UCHL1/ PGP9.5 is highly specific for neurons and cells of the diffuse neuroendocrine system and their tumors [1, 2]. To understand the development and function of the nervous system, precise visualization of the neuronal compartments is needed. UCHL1 specifically labels the neuronal cell body and axon of the central and peripheral neural system [3]. 

This protein is present in brain tissue at concentrations at least 50 times greater than in other organs and is a major protein component of neuronal cytoplasm [4]. UCHL1/ PGP9.5 is also a Parkinson's disease susceptibility gene [5].

UCHL1/PGP9.5 as a tumor marker

Recent studies also investigate the relationship between UCHL1/ PGP9.5 and many different human cancer types. PGP9.5 was reported to be overexpressed in a subset of human cancers, such as colorectal, pancreatic, lung, or gallbladder cancer [6-9]. However, it remains unclear how UCHL1/ PGP9.5 is involved in the tumorigenic pathway.

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Protein Ladders
Prestained Protein Ladder (free samples available) Broad Range Prestained Protein Ladder 
Molecular weight coverage: 10-180 kDa Molecular weight coverage: 3-245 kDa
Catalog no.: PL00001
Catalog no.: PL00002
prestained protein marker with 10 markers covering a wide range of molecular weights from 10 to 180 kDa broad range prestained protein marker with 13 markers covering a wide range of molecular weights from 3 to 245 kDa
Resolution of the prestained protein ladder in a 10-20% Tris-glycine gel (SDS-PAGE). The image shows the migration pattern in the gel and after transfer to a PVDF membrane. Resolution of the prestained protein ladder in a 4-12% Bis-Tris gel (SDS-PAGE). The image shows the migration pattern in the gel and after transfer to a PVDF membrane.

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Posted:
31 March, 2020

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