Tested Applications
| Positive IHC detected in | human stomach tissue, mouse stomach tissue, mouse heart tissue Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0 |
Recommended dilution
| Application | Dilution |
|---|---|
| Immunohistochemistry (IHC) | IHC : 1:50-1:500 |
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, Check data in validation data gallery. | |
Product Information
23781-1-AP targets ADM2 in IF, IHC, ELISA applications and shows reactivity with human, mouse samples.
| Tested Reactivity | human, mouse |
| Cited Reactivity | human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen |
CatNo: Ag20548 Product name: Recombinant human ADM2 protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 1-148 aa of BC012864 Sequence: MARIPTAALGCISLLCLQLPGSLSRSLGGDPRPVKPREPPARSPSSSLQPRHPAPRPVVWKLHRALQAQRGAGLAPVMGQPLRDGGRQHSGPRRHSGPRRTQAQLLRVGCVLGTCQVQNLSHRLWQLMGPAGRQDSAPVDPSSPHSYG Predict reactive species |
| Full Name | adrenomedullin 2 |
| Calculated Molecular Weight | 16 kDa |
| GenBank Accession Number | BC012864 |
| Gene Symbol | ADM2 |
| Gene ID (NCBI) | 79924 |
| RRID | AB_2879322 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen Affinity purified |
| UNIPROT ID | Q7Z4H4 |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. |
| Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA. |
Background Information
ADM2 also named as adrenomedullin 2 or IMDS is a 148 amino-acid secreted protein, which belongs to adrenomedullin family of calcitonin-related peptide hormones and is expressed in the esophagus, stomach, jejunum, ileum, ileocecum, ascending colon, transverse colon, descending colon and rectum. ADM2 activates the cAMP-dependent pathway and may play a role in regulating gastrointestinal and cardiovascular bioactivities. ADM2 play a role in the regulation of peripheral tissues by calcitonin receptor-like receptor.
Protocols
| Product Specific Protocols | |
|---|---|
| IHC protocol for ADM2 antibody 23781-1-AP | Download protocol |
| Standard Protocols | |
|---|---|
| Click here to view our Standard Protocols |
Publications
What published studies show
The ADM2 polyclonal antibody (Cat# 23781-1-AP) has 1 total citation. It was cited in Frontiers in Immunology (2022), in a study investigating adrenomedullin expression associated with severity and poor prognosis of interstitial lung disease in dermatomyositis patients. The research field is immunology, specifically autoimmune-mediated lung disease.
| Species | Application | Title |
|---|---|---|
Front Immunol Adrenomedullin Expression Is Associated With the Severity and Poor Prognosis of Interstitial Lung Disease in Dermatomyositis Patients. |
