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  • Western Blot (WB) analysis of various lysates using ANAPC11 Polyclonal antibody (15065-1-AP)

    WB analysis using 15065-1-AP

    Various lysates were subjected to SDS PAGE followed by western blot with 15065-1-AP (ANAPC11 antibody) at dilution of 1:800 incubated at room temperature for 1.5 hours.

ANAPC11 Polyclonal antibody

ANAPC11 Polyclonal Antibody for WB, ELISA
Cat No. 15065-1-AP

Review Product

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, ELISA

Synonyms

APC11, ANAPC 11, Anaphase-promoting complex subunit 11, Apc 11, Apc 11p

Formulation:  PBS and Azide
PBS and Azide
Conjugate:  Unconjugated
Unconjugated
Size/Concentration: 

-/ -

Freight/Packing: -

Quantity

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Tested Applications

Positive WB detected inmouse testis tissue, rat testis tissue

Recommended dilution

ApplicationDilution
Western Blot (WB)WB : 1:500-1:1000
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

15065-1-AP targets ANAPC11 in WB, ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Reactivity human, mouse, rat
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen ANAPC11 fusion protein Ag7069 Predict reactive species
Full Name anaphase promoting complex subunit 11
Calculated Molecular Weight21 kDa, 10 kDa
Observed Molecular Weight 21 kDa
GenBank Accession NumberBC000607
Gene Symbol APC11
Gene ID (NCBI) 51529
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
UNIPROT IDQ9NYG5
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.

Background Information

Anaphase-promoting complex subunit 11 (ANAPC11) is a core catalytic subunit of the anaphase-promoting complex/cyclosome (APC/C). ANAPC11 is involved in the ubiquitination and degradation of key cell cycle regulators, including cyclin B and securin, facilitating the transition from metaphase to anaphase during cell division (PMID: 11739784; 18485873). ANAPC11 also mediates the ubiquitination and degradation of the Forkhead transcription factor FOXO3, promoting cell proliferation and lymph node metastasis in urothelial bladder cancer (PMID: 37573356).

Protocols

Product Specific Protocols
WB protocol for ANAPC11 antibody 15065-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols