AXL Antibody
Rabbit Polyclonal
Catalog number: 13196-1-AP
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Applications
| Tested applications | ELISA, WB, IP |
| Cited applications | |
| Species specificity | human, mouse, rat; other species not tested. |
| Cited species | |
| Positive WB detected in | HepG2 cells, HeLa cells, human liver tissue, HT-1080 cells |
| Recommended dilution | WB: 1:500-1:5000 |
Application key: WB = Western blotting, IHC = Immunohistochemistry, IF = Immunofluorescence,
IP = Immunoprecipitation
IP = Immunoprecipitation
Images
IP result of anti-AXL (13196-1-AP for IP and Detection) with HeLa cell lysate.
HepG2 cells were subjected to SDS PAGE followed by western blot with 13196-1-AP(AXL Antibody) at dilution of 1:1500
Product Information
| Source | Rabbit | Purification method | Antigen affinity purification |
| Isotype | IgG | Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. |
Immunogen Information
| Immunogen | AXL fusion protein ag3898 | Full name | AXL receptor tyrosine kinase |
|
Calculated molecular weight |
894aa,98kd |
Observed molecular
weight |
140kd |
|
GenBank accession number |
BC032229 | Gene ID (NCBI) | 558 |
| Gene symbol | AXL | Synonyms | JTK11; UFO |
Background
Axl, also known as Ufo or Ark, is a receptor tyrosine kinase of the TAM (Tyro3, Axl and Mer) family. Axl is a single-pass type I membrane protein containing two fibronectin type-III domains, two Ig-like C2-type domains and one protein kinase domain. Axl mRNA is widely expressed with highest levels in the heart and skeletal muscle. Gas6 has been identified as a ligand for human Axl. Gas6/Axl signaling plays a role in cell survival, cell proliferation, migration and differentiation. This antibody detects a single band at 140 kDa, which is considered to represent the auto-phosphorylated form of endogenous Axl (PMID: 12730092). |
