BAK Antibody
Rabbit Polyclonal
Catalog number: 14673-1-AP
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Applications
| Tested applications | ELISA, WB, IHC |
| Cited applications | IHC, WB |
| Species specificity | human, mouse, rat; other species not tested. |
| Cited species | human, mouse |
| Positive WB detected in | Jurkat cells |
| Positive IHC detected in | human lymphoma |
| Recommended dilution | WB: 1:1000-1:10000 IHC: 1:50-1:200 |
Application key: WB = Western blotting, IHC = Immunohistochemistry, IF = Immunofluorescence,
IP = Immunoprecipitation
IP = Immunoprecipitation
Images
Jurkat cells were subjected to SDS PAGE followed by western blot with 14673-1-AP(BAK Antibody) at dilution of 1:3000
Immunohistochemistry of paraffin-embedded human lymphoma using 14673-1-AP(BAK Antibody) at Dilution 1:100 (under 10x lens)
Immunohistochemistry of paraffin-embedded human lymphoma using 14673-1-AP(BAK Antibody) at Dilution 1:100 (under 40x lens)
Product Information
| Source | Rabbit | Purification method | Antigen affinity purification |
| Isotype | IgG | Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. |
Immunogen Information
| Immunogen | BAK fusion protein ag6354 | Full name | BCL2-antagonist/killer 1 |
|
Calculated molecular weight |
23kd |
Observed molecular
weight |
28kd |
|
GenBank accession number |
BC004431 | Gene ID (NCBI) | 578 |
| Gene symbol | BAK1 | Synonyms | BAK; BAK-LIKE; BCL2L7; CDN1; MGC117255; MGC3887 |
Background
BAK1, also named as BAK, BCL2L7 and CDN1, belongs to the Bcl-2 family. In the presence of an appropriate stimulus, BAK1 accelerates programmed cell death by binding to, and antagonizing the anti-apoptotic action of BCL2 or its adenovirus homolog E1B 19k protein. Low micromolar levels of zinc ions inhibit the promotion of apoptosis. (PMID:17157251) BAK1 gene product primarily enhances apoptotic cell death following an appropriate stimulus. It can inhibit cell death in an Epstein-Barr virus-transformed cell line. |
