CD59 Antibody
Rabbit Polyclonal
Catalog number: 10742-1-AP
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Applications
| Tested applications | ELISA, WB, IHC |
| Cited applications | WB |
| Species specificity | human; other species not tested. |
| Cited species | human |
| Positive WB detected in | BxPC-3 cells, human brain tissue |
| Positive IHC detected in | human ovary tumor |
| Recommended dilution | WB: 1:200-1:2000 IHC: 1:50-1:200 |
Application key: WB = Western blotting, IHC = Immunohistochemistry, IF = Immunofluorescence,
IP = Immunoprecipitation
IP = Immunoprecipitation
Images
BxPC-3 cells were subjected to SDS PAGE followed by western blot with 10742-1-AP(CD59 Antibody) at dilution of 1:600
Immunohistochemistry of paraffin-embedded human ovary tumor using 10742-1-AP(CD59 Antibody) at Dilution 1:100 (under 10x lens)
Product Information
| Source | Rabbit | Purification method | Antigen affinity purification |
| Isotype | IgG | Storage | PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. |
Immunogen Information
| Immunogen | CD59 fusion protein ag1173 | Full name | CD59 molecule, complement regulatory protein |
|
Calculated molecular weight |
19kd |
Observed molecular
weight |
18-20kd |
|
GenBank accession number |
BC001506 | Gene ID (NCBI) | 966 |
| Gene symbol | CD59 | Synonyms | 16.3A5; 1F5; EJ16; EJ30; EL32; FLJ38134; FLJ92039; G344; HRF-20; HRF20; MAC-IP; MACIF; MEM43; MGC2354; MIC11; MIN1; MIN2; MIN3; MIRL; MSK21; p18-20 |
Background
CD59, also named as MIC11, MIN1, MIN2, MIN3, MSK21, MIRL, MACIF, HRF20 and 1F5 antigen, is a cell surface molecule glycoprotein with MW 18-25kd. It acts as a determinant of proximal–distal cell identity. CD59 acts by binding to the C8 and/or C9 complements of the assembling membrane attack complex (MAC), thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. It is involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase. |
