COMMD1 Antibody
Rabbit Polyclonal
Catalog number: 11938-1-AP
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Applications
| Tested applications | ELISA, WB, IHC |
| Cited applications | IF, WB |
| Species specificity | human, mouse, rat; other species not tested. |
| Cited species | human, mouse |
| Positive WB detected in | human liver tissue, HeLa cells, HepG2 cells, human brain tissue, human heart tissue, mouse brain tissue |
| Positive IHC detected in | human liver cancer |
| Recommended dilution | WB: 1:1000-1:10000 IHC: 1:20-1:200 |
Application key: WB = Western blotting, IHC = Immunohistochemistry, IF = Immunofluorescence,
IP = Immunoprecipitation
IP = Immunoprecipitation
Images
human liver tissue were subjected to SDS PAGE followed by western blot with 11938-1-AP(COMMD1 Antibody) at dilution of 1:2000
Immunohistochemistry of paraffin-embedded human liver cancer using 11938-1-AP(COMMD1 Antibody) at Dilution 1:50 (under 10x lens)
Immunohistochemistry of paraffin-embedded human liver cancer using 11938-1-AP(COMMD1 Antibody) at Dilution 1:50 (under 40x lens)
Product Information
| Source | Rabbit | Purification method | Antigen affinity purification |
| Isotype | IgG | Storage | PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. |
Immunogen Information
| Immunogen | COMMD1 fusion protein ag2535 | Full name | copper metabolism (Murr1) domain containing 1 |
|
Calculated molecular weight |
190aa,21kd |
Observed molecular
weight |
21kd |
|
GenBank accession number |
BC022046 | Gene ID (NCBI) | 150684 |
| Gene symbol | COMMD1 | Synonyms | C2orf5; MGC27155; MURR1 |
Background
COMMD1(COMM domain-containing protein 1), also named MURR1, is implicated in copper homeostasis by binding one copper ion per monomer. COMMD1 was reported to accelerate the ubiquitination and degradation of NF-kappa-B subunits, its deficiency exerts enhanced NF-kappa-B mediated celluar response. Ubiquitinated by XIAP (X-linked inhibitor of apoptosis), COMMD1 undergoes proteasomal degradation. SOD1 activity can be downregulated by COMMD1. |
