DHX58 Antibody
Rabbit Polyclonal
Catalog number: 11355-1-AP
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Applications
| Tested applications | ELISA, WB, IHC, IP |
| Cited applications | WB |
| Species specificity | human, mouse, rat; other species not tested. |
| Cited species | human, mouse |
| Positive WB detected in | mouse liver tissue, HEK-293 cells, human liver tissue, L02 cells |
| Positive IHC detected in | human breast cancer |
| Recommended dilution | WB: 1:200-1:1000 IHC: 1:10-1:100 |
Application key: WB = Western blotting, IHC = Immunohistochemistry, IF = Immunofluorescence,
IP = Immunoprecipitation
IP = Immunoprecipitation
Images
IP result of DHX58 antibody (11355-1-AP for IP and Detection) with mouse liver tissue lysate.
mouse liver tissue were subjected to SDS PAGE followed by western blot with 11355-1-AP(DHX58 Antibody) at dilution of 1:400
Immunohistochemistry of paraffin-embedded human breast cancer using 11355-1-AP(DHX58 Antibody) at Dilution 1:10 (under 10x lens)
Product Information
| Source | Rabbit | Purification method | Antigen affinity purification |
| Isotype | IgG | Storage | PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. |
Immunogen Information
| Immunogen | DHX58 fusion protein ag1910 | Full name | DEXH (Asp-Glu-X-His) box polypeptide 58 |
|
Calculated molecular weight |
678aa,77kd |
Observed molecular
weight |
66kd,55kd,45kd |
|
GenBank accession number |
BC014949 | Gene ID (NCBI) | 79132 |
| Gene symbol | DHX58 | Synonyms | D11LGP2; D11lgp2e; LGP2 |
Background
DHX58(Probable ATP-dependent RNA helicase DHX58) is also named as D11LGP2E, LGP2 and belongs to the RLR subfamily. DHX58, originally identified as a highly expressed gene in mammary tumors, is another cytoplasmic DEX(D/H)-box helicase that can recognize RNA(PMID: 18411269). It acts as a positive, but not negative, regulator of RIG-I– and MDA5-dependent recognition of RNA virus infection and plays a pivotal role in antiviral responses in vivo(PMID:20080593). This antibody is specific to DHX58. |
