DNA2 Antibody
Rabbit Polyclonal
Catalog number: 18727-1-AP
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Applications
| Tested applications | ELISA, IHC |
| Cited applications | |
| Species specificity | human; other species not tested. |
| Cited species | |
| Positive IHC detected in | human cervical cancer |
| Recommended dilution | IHC: 1:20-1:200 |
Application key: WB = Western blotting, IHC = Immunohistochemistry, IF = Immunofluorescence,
IP = Immunoprecipitation
IP = Immunoprecipitation
Images
Immunohistochemistry of paraffin-embedded human cervical cancer using 18727-1-AP(DNA2 Antibody) at Dilution 1:50 (under 10x lens)
Immunohistochemistry of paraffin-embedded human cervical cancer using 18727-1-AP(DNA2 Antibody) at Dilution 1:50 (under 40x lens)
Product Information
| Source | Rabbit | Purification method | Antigen affinity purification |
| Isotype | IgG | Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. |
Immunogen Information
| Immunogen | Peptide | Full name | DNA replication helicase 2 homolog (yeast) |
|
Calculated molecular weight |
120kd |
Observed molecular
weight |
|
|
GenBank accession number |
NM_001080449 | Gene ID (NCBI) | 1763 |
| Gene symbol | DNA2 | Synonyms | DNA2L; FLJ10063; KIAA0083; MGC133297 |
Background
DNA2(DNA replication ATP-dependent helicase/nuclease DNA2) is also named as DNA2L, KIAA0083 and belongs to the DNA2/NAM7 helicase family. This protein includes 2 domains: DNA replication nuclease and DNA replication ATP-dependent helicase. It is a conserved helicase/nuclease involved in the maintenance of mitochondrial and nuclear DNA stability and it can interact with DNA polymerase gamma and stimulating its activity. It can also process intermediate 5' flap structures occuring in DNA replication long-patch base excision repair in mitochondria. It has 4 isoforms produced by alternative splicing. This antibody is specific to DNA2. |
