DOCK3; MOCA Antibody
Rabbit Polyclonal
| Tested applications | ELISA, WB |
| Cited applications | |
| Species specificity | human, mouse; other species not tested. |
| Cited species | |
| Positive WB detected in | human brain tissue, SH-SY5Y cells |
| Recommended dilution | WB: 1:500-1:5000 |
IP = Immunoprecipitation
human brain tissue were subjected to SDS PAGE followed by western blot with 20683-1-AP(DOCK3; MOCA Antibody) at dilution of 1:1000
| Source | Rabbit | Purification method | Antigen affinity purification |
| Isotype | IgG | Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. |
| Immunogen | Peptide | Full name | dedicator of cytokinesis 3 |
|
Calculated molecular weight |
233kd |
Observed molecular
weight |
233kd |
|
GenBank accession number |
NM_004947 | Gene ID (NCBI) | 1795 |
| Gene symbol | DOCK3 | Synonyms | KIAA0299; MOCA; PBP |
Dedicator of cytokinesis3 (DOCK3) , also named as MOCA and PBP , is a ~180 kDa protein involved in signaling trasduction. It is a potential guanine nucleotide exchange factor (GEF) which activate some small GTPases by exchanging bound GDP for free GTP. DOCK3 is associated in Alzheimer disease tangles and regulates the accumulation of amyloid precursor protein and beta-amyloid. Overexpression of Dock3 in neural cells promotes axonal outgrowth downstream of brain-derived neurotrophic factor (BDNF) signaling. DOCK3 binds to and inactivates glycogen synthase kinase-3β (GSK-3β) at the plasma membrane, thereby promoteing axon branching and microtubule assembly. By stimulating actin polymerization and microtubule assembly, DOCK3 plays important roles downstream of BDNF signaling in the CNS. |
