EPCAM Antibody
Rabbit Polyclonal
Catalog number: 21050-1-AP
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Applications
| Tested applications | ELISA, WB, IHC |
| Cited applications | FACS, WB |
| Species specificity | human, mouse; other species not tested. |
| Cited species | human, rat |
| Positive WB detected in | A431 cells, COLO 320 cells, mouse colon tissue |
| Positive IHC detected in | human breast cancer |
| Recommended dilution | WB: 1:200-1:2000 IHC: 1:50-1:200 |
Application key: WB = Western blotting, IHC = Immunohistochemistry, IF = Immunofluorescence,
IP = Immunoprecipitation
IP = Immunoprecipitation
Images
A431 cells were subjected to SDS PAGE followed by western blot with 21050-1-AP(EPCAM Antibody) at dilution of 1:800
Immunohistochemistry of paraffin-embedded human breast cancer using 21050-1-AP(EPCAM Antibody) at Dilution 1:100 (under 10x lens)
Immunohistochemistry of paraffin-embedded human breast cancer using 21050-1-AP(EPCAM Antibody) at Dilution 1:100 (under 40x lens)
Product Information
| Source | Rabbit | Purification method | Antigen affinity purification |
| Isotype | IgG | Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. |
Immunogen Information
| Immunogen | EPCAM fusion protein ag15393 | Full name | epithelial cell adhesion molecule |
|
Calculated molecular weight |
314aa,35kd |
Observed molecular
weight |
40kd,45-50kd |
|
GenBank accession number |
BC014785 | Gene ID (NCBI) | 4072 |
| Gene symbol | EPCAM | Synonyms | CO-17A; CO17-1A; EGP; EGP-2; EGP34; EGP40; ESA; Ep-CAM; GA733-2; KS1/4; KSA; M4S1; MIC18; MK-1; TACST-1; TACSTD1; TROP1; hEGP-2 |
Background
Epithelial cell adhesion molecule (EpCAM, CD326) is a type I transmembrane glycoprotein that functions as a homophilic, epithelial-specific intercellular cell-adhesion molecule. In addition to cell adhesion, EpCAM is also involved in cellular signaling, cell migration, proliferation, and differentiation. EpCAM is highly expressed on most carcinomas and therefore of potential use as a diagnostic and prognostic marker for a variety of carcinomas, and has become a therapeutic target. (PMID: 20837599; 19249674; 21576002; 22647938) |
