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Applications
| Tested Applications: | ELISA,IHC |
| Specificity Reaction: | Human,Mouse,Rat; Other species are not tested.Please decide the specificity by homology |
| Positive IHC detected In: | Ovary cancer |
Application key: WB=Western Blotting ,IHC=Immunohistochemistry, IF=Immunofluorescence
Images
Immunohistochemistry of paraffin-embedded Ovary cancer using 11236-2-AP(FLCN Antibody) at Dilution 1:50 (under 40x lens)
Product Information
| Source: | Rabbit | Purify: | Antigen Affinity purified |
| IsoType: | IgG | Storage: | PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20oC, Avoid freeze / thaw cycles. |
Immunogen Information
| Immunogen: | FLCN fusion protein ag1746 | Full Name: | folliculin |
|
Caculated Molecular Weight: |
38kd |
Observed Molecular
Weight: |
|
| GenbankNo | BC015687 | GeneID: | 201163 |
| Symbol | FLCN | Synonyms | FLCN;BHD;DKFZp547A118;FLCL;FLJ45004;FLJ99377;MGC17998;MGC23445 ; |
Background
FLCN, also named as BHD, belongs to the folliculin family. It may play a role in the pathogenesis of an uncommon form of kidney cancer through its association with an inherited disorder of the hair follicle (fibrofolliculomas). FLCN may be a tumor suppressor. It is involved in colorectal tumorigenesis. It may be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. Mutation of FLCN may cause the BHD(Birt-Hogg-Dube syndrome ) or (PSP) primary spontaneous pneumothorax. And it may be involved in renal cell carcinoma. This antibody can recognize all the 3 isoforms of FLCN. |
