VEGFR1, FLT1 Antibody
Rabbit Polyclonal
| Tested applications | ELISA, WB, IP |
| Cited applications | |
| Species specificity | human, mouse, rat; other species not tested. |
| Cited species | |
| Positive WB detected in | HEK-293 cells, human placenta tissue, mouse lung tissue |
| Recommended dilution | WB: 1:200-1:2000 |
IP = Immunoprecipitation
IP result of anti-FLT1 (13687-1-AP for IP and Detection) with A549 cell lysate.
HEK-293 cells were subjected to SDS PAGE followed by western blot with 13687-1-AP(VEGFR1, FLT1 Antibody) at dilution of 1:800
| Source | Rabbit | Purification method | Antigen affinity purification |
| Isotype | IgG | Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. |
| Immunogen | VEGFR1, FLT1 fusion protein ag4558 | Full name | fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) |
|
Calculated molecular weight |
1338aa,151kd |
Observed molecular
weight |
55-60kd |
|
GenBank accession number |
BC039007 | Gene ID (NCBI) | 2321 |
| Gene symbol | FLT1 | Synonyms | FLT; VEGFR1 |
Vascular endothelial growth factor receptor 1 (VEGFR1, FLT1) is a receptor tyrosine kinase belonging to the VEGFR family. VEGF is a key regulator of physiological angiogenesis and has also been implicated in pathological angiogenesis associated with tumors, intraocular neovascular disorders and other conditions. The biological effects of VEGF are mediated by VEGFR1 and VEGFR2. Both the two receptors have seven immunoglobulin-like repeats in the extracellular domain, a single transmembrane region and a tyrosine kinase domain. VEGFR1 binds VEGFA, PIGF and VEGFB, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migration, macrophage function, chemotaxis, and cancer cell invasion. Two isoforms of VEGFR1 exist, a full-length transmembrane form and a short souble form (sVEGFR1) consisting of only the extracellular ligand-binding domain. (PMID: 12778165; 17109193; 8806634) |
